Epigenetics

Epigenetics – “Epi-“means on or above in Greek,and “epigenetic”. Epigenetics means how cells control gene activity without changing the DNA sequence. Epigenetic changes make modification in DNA that regulate whether genes are turned on or off. These modifications are attached to DNA and do not change the sequence of DNA. It influence the production of proteins in cells. Environmental influences, such as a person’s diet and pollutants impact the epigenome and in some cases, can be inherited through the generations. A common type of epigenetic modification is called DNA methylation. DNA methylation is mediated by DNA-methyl transferase (DNMT), DNMT1 which preserves pre-existing pattern of methylation after cell replication, and DNMT3A/B, “de novo” DNMT, which methylate previously unmethylated DNA. Histone modifications are of acetylation, methylation and  phosphorylation. The acetylation of histones is mediated by histone acetyltransferases (HATs) and histone deacetyltransferases (HDACs), The accumulated evidence indicates that many genes, diseases are part of the epigenetics picture.

Researchers are investigating many drugs that function through epigenetic mechanisms. Drugs that inhibit DNA methylation or histone deacetylation. Scientists continue to explore the relationship between the genome and the chemical compounds that modify it. In particular, they are studying the effects that epigenetic modifications and errors have on gene function, protein production, and human health.

We are the largest Epigenetics  distributor of inhibitors in India. Here is list of inhibitors.

JQ-1, Curcumin, A-485, Revumenib, Inobrodib,Birabresib, Camptothecin, Diosgenin, MicroRNA supplier in India.

 We are top-notch provider of Epigenetic reader domain, Non-coding RNA, Histone Modification and DNA Methylation.

We are supplier of Epigenetic related products HuR, siRNA, MicroRNA, SF3B1, AMPK, DNA methyltransferase, JAK, TET protein, PKC, PARP.